Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine\r\n(TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study,\r\nTCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan\r\nBi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration. Metabolomic technique was used to evaluate\r\nthe pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration significantly increased\r\nthe severity of the arthritis in rats but was ameliorated by YJB. Its pharmacological mechanism was partially associated with lipid\r\nmetabolites involving free fatty acid (FFA) and lysophosphatidylcholine (LPC). In conclusion, the experimental results demonstrate\r\nthe protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that\r\nYJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern.
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